In nine separate studies on four patients with severe pitting edema, aldosterone secretion fell during a 24-hour period of acute salt and water depletion induced by diuretics. These results contrast ...

Nine normal volunteer subjects (6 males and 3 females), nineteen to thirty-six years of age, and 5 patients with primary aldosteronism (3 females and 2 males), forty to fifty-two years of age, were ...

Higher serum aldosterone levels among patients with chronic kidney disease (CKD) are independently associated with an increased risk for CKD progression and end-stage kidney disease (ESKD) regardless ...

A drug that has been used to slow progression of kidney and cardiovascular disease in people with type 2 diabetes may also help people with chronic kidney disease who do not have diabetes, according ...

Current treatment options for primary aldosteronism are limited to surgery or mineralocorticoid receptor antagonists when surgery isn't an option. In a phase IIa trial, baxdrostat resolved or reduced ...

Of note, recent studies by Williams’s group have indicated a relationship between aldosterone and adipose tissue deposition: a higher 24-h urinary aldosterone excretion and PAC after angiotensin (Ang) ...

AstraZeneca’s BAXFENDY™ (baxdrostat) has been approved in the US as a first-in-class aldosterone synthase inhibitor (ASI) for the treatment of hypertension in combination with other antihypertensive ...

Translational research is often given an unidirectional sense, ‘from benchtop to bedside’. Before the ascendancy of cellular and molecular biology insights into mechanisms of disease (and in turn, of ...

An aldosterone (ALD) test measures the amount of ALD in your blood. It’s also called a serum aldosterone test. ALD is a hormone made by the adrenal glands. The adrenal glands are found on top of your ...

Please provide your email address to receive an email when new articles are posted on . Aldosterone is associated with an increased risk of chronic kidney disease progression and the development of ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

The coronavirus disease 2019 (COVID-19) pandemic caused millions of deaths throughout the world, which has provoked intense research into the pathogenetic mechanism behind this disease. A new study ...