Phosphoinositides are a family of membrane lipids distinguished by phosphate groups at specific positions on the inositol ring, acting as spatial and temporal organisers of cell activity. Through ...

UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors that many common medicines target. Scientists at the University of North ...

Calcineurin is a ubiquitous serine/threonine phosphatase that decodes calcium signals to regulate an array of cellular functions. Its activation requires calcium binding to calmodulin and the ...

In a recently published review, a research team led by MedUni Vienna has highlighted a promising new approach to drug discovery. The focus is on the targeted modulation of certain intracellular ...

The Universitat Autònoma de Barcelona (UAB) and the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) have developed ...

The expanding interest in small bioactive peptides has brought renewed attention to glycyl-L-histidyl-L-lysine bound to ...

Ribosomes don’t just make proteins—they can sense when something’s wrong. When they collide, they send out stress signals that activate a molecule called ZAK. Researchers uncovered how ZAK recognizes ...

This is a confocal section of an embryo where in one half (right; cells with cyan nuclei), adhesion is decreased by using an optogenetic tool. The left half is epithelialised with tricellular contacts ...

Peptide research has expanded dramatically as investigators continue to explore short amino acid chains that participate in ...

Researchers at Texas A&M Health and collaborators have developed engineered CRAC channel inhibitory binders that can ...

Researchers at NYU College of Dentistry have uncovered what may be biologically driving oral health issues unique to Down syndrome. Their study, published in Cell Reports, describes a molecular ...