CRISPR–Cas effectors typically rely on RNA guides to recognize target sequences. In Cas12a, the protospacer adjacent motif on DNA engages conserved protein residues, triggering target binding and ...
The eukaryotic genome is prevalently transcribed and produces a vast array of distinct RNAs 1. Some RNAs, in particular long non-coding RNAs (lncRNAs), interact with chromatin by being either ...
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