The process of GLUT4 trafficking is central to the metabolic regulation of blood glucose levels. In both muscle and adipose cells, the insulin hormone triggers the mobilisation of intracellular ...

As their name implies, glucose transporter proteins act as vehicles to ferry glucose inside the cell. To get detailed images of how GLUT4 is transported and moves through the cell membrane, the ...

Insulin is essential for glucose homeostasis and one of its key functions is to drive glucose uptake into adipocytes and myocytes. Insulin’s role in this process became apparent in 1921 and the ...

The role of the adapter protein PICALM in the development of Alzheimer's disease is well documented. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), the German ...

A group of researchers has clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by developing a method for visualizing intracellular trafficking of proteins. A group of ...

The common forms of type 2 diabetes are caused by a constellation of genetic and epigenetic factors and molecular changes related to diet; lifestyle, including lack of exercise and sleep; ...

A group of researchers led by Kazuya Kikuchi, professor at the Graduate School of Engineering, Osaka University, clarified the role of a N-glycan chain on glucose transporter type 4 (GLUT4) by ...