This review examines how CAR-T cell therapy is expanding beyond blood cancers into solid tumors, autoimmune diseases, chronic ...

Cancers that were once considered incurable now have new treatment options. Among these innovations are CAR-T (chimeric antigen receptor T cell) therapies that modify a patient's T cells, which play ...

A bone marrow transplant can buy time for people with aggressive B-cell cancers. Too often, it does not buy enough. For ...

CAR T-cell therapy has transformed the treatment of hematologic malignancies, yet many patients do not achieve lasting ...

An early-stage trial indicates that CAR-T therapy using T memory stem cells may enable certain blood cancer patients to avoid pre-treatment chemotherapy. The modified therapy achieved higher complete ...

In multiple myeloma, plasma cells proliferate uncontrollably in the bone marrow, disrupting the growth of healthy blood-forming cells. If the disease recurs after treatment or fails to respond, CAR ...

There has been a swing towards in vivo CAR-T therapies lately, as big pharmas sign acquisition deals and new therapies hit ...

Stem-cell memory T (TSCM) cells are a rare subset of immune cells with the ability to self-renew, persist long term, and ...

Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized treatment for various blood cancers. When traditional treatments fail, CAR-T therapies provide a second highly effective option.

I f your doctor has recommended chimeric antigen receptor (CAR) T-cell immunotherapy for large B-cell lymphoma (LBCL), you’ve likely already tried several standard treatments, and the cancer did not ...