Doris Lin is an animal rights attorney and the Director of Legal and Government Affairs for the Animal Protection League of New Jersey. Her focuses as an expert writer include animal rights and ...

LD50 data was NOT used: * for selecting a starting dose in human trials. Companies used either non-rodent data or repeat-dose studies in mice instead. * in determining the most affected organ.

Rat LD50 values were taken from the Registry of Toxic Effects of Chemical Substances (RTECS) database [55] and cytotoxicity values were taken from the public National Cancer Institute (NCI) ...

Background: Quantitative structure-activity relationship (QSAR) models have become popular tools to help identify promising lead compounds in anticancer drug development. Few QSAR studies have ...