Notre Dame is a 7.5 point favorite against Indiana, according to the lines posted to FanDuel Sportsbook for the matchup. FanDuel set the total at 51.5 points for the game (Over -105, Under -115).
Both teams have strong records against the spread. According to TeamRankings, Notre Dame is 9-2-1 and Indiana is 9-3. However, the Hoosiers' last road win over a ranked team came in 2014.