Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and ...

Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...

Image Caption: Pyruvate inhibits TNFα/NF-κB signaling and the expression of downstream pro-inflammatory genes. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Chemists have developed an organic catalyst that can drive reactions using pyruvate -- a key biomolecule in many metabolic pathways -- that are difficult and complicated to achieve using conventional ...

Ulcerative colitis (UC) is a chronic inflammatory disease marked by intestinal pain, bleeding, and impaired gut barrier function. At the heart of the disease lies TNFα-induced NF-κB signaling, which ...