For adults with type 2 diabetes (T2D), a ketogenic diet (KD) reduces the proportion of proinsulin secreted to a greater extent than a low-fat diet (LFD), acco ...

Specially packaged DNA secreted by tumor cells can trigger an immune response that inhibits the metastatic spread of the tumor to the liver, according to a new study. The discovery improves the ...

Many drugs work by targeting proteins. Biologic medicines showed that proteins can be made into therapies too—in some cases using proteins from the body. Juvena Therapeutics works with a type of ...

Though Aβ tends to hog the research spotlight, scientists have steadily built a case for the importance of another APP fragment—secreted APP. Now, a paper in the January 11 Science explains how it ...

Senescent cells undergo an irreversible and permanent arrest of cell division and are hallmarks of both the aging process and multiple chronic diseases. Senescent cells -- and more importantly the ...

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), encompasses a spectrum of conditions ranging from simple steatosis to ...

The first evidence that fat cells have a role beyond storing energy from excess food came from a strain of massively obese mutant mice. Before these mice, some researchers had suspected the cells were ...