Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...
In contemporary society, obesity has emerged as a worldwide chronic metabolic disorder, imposing substantial burdens on both individual health and healthcare systems. The insulin resistance that ...
A phase 2 study of intravenous pembrolizumab and intratumorally injected autologous dendritic cells (DCs) in refractory colorectal cancer (CRC). This is an ASCO Meeting Abstract from the 2025 ASCO ...
Engineering PBAE nanoparticles for immunological reprogramming in clinically relevant humanized mouse models. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does ...
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