Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix components during tissue development, homeostasis, repair and disease. Despite this crucial role, the ...

Cell types are defined by their unique morphological and functional features, which are reflected in the set of genes they express. The international Human Cell Atlas (HCA) initiative aims to ...

Genetic studies have revealed many genes linked to both common and rare disease, but to understand how those genes bring about disease and use those insights to help develop therapies, scientists need ...

This activity was supported by Contract/Task Order No. 28321318D00060015/00003 between the National Academy of Sciences and the U.S. Social Security Administration. Any opinions, findings, conclusions ...

The U.S. Social Security Administration has requested the National Academies of Sciences, Engineering, and Medicine establish an ad hoc committee to review certain heritable conditions related to ...