Major mechanisms for the recognition of pathogens by immune cells have evolved to employ classical and non-classical major histocompatibility complex class I (MHC I) molecules. Classical MHC I ...

Why MHC Tetramers? T cells play essential effectors and regulatory roles in adaptive immune responses to tumors, viruses, bacteria, parasites, transplanted tissues, allergens and even to self antigens ...

The major histocompatibility complex (MHC) region plays a crucial role in immune function; therefore, any genetic or epigenetic polymorphisms within the MHC locus may result in various diseases ...

Predict, Predict! A modification of the computational tool AlphaFold predicts T cell receptor:peptide-MHC interactions.

Our core provides customized MHC/peptide tetramers for identification of antigen-specific T lymphocytes by flow cytometry. Tetramers and/or their derivatives are provided for research purposes only.