Abnormal axonal transport is associated with neuronal disease. We identified a role for DHC-1, the C. elegans dynein heavy chain, in maintaining neuronal cargo distribution. Surprisingly, this does ...

PURPOSE: To analyze the available data concerning mechanisms of action of and mechanisms of resistance to the antitubulin agents, vinca alkaloids and taxanes, and more recently described compounds.

A multi-institutional research collaboration has revealed that the microtubule network (*1), which plays a vital role in cell construction and polarization (*2), utilizes the phase separation (*3) ...

Microtubule plus-end tracking proteins (+TIPs) play key roles in the regulation of microtubule dynamics in vivo. These proteins bind to and regulate microtubule “plus‐ends”, which are the dynamic ends ...

Robert Blackwell, Oliver Sweezy-Schindler, Christopher Edelmaier, Zachary R. Gergely, Patrick J. Flynn, Salvador Montes, Ammon Crapo, Alireza Doostan, J. Richard ...

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes, and ...

The motion of motor proteins on biopolymers is important for diverse biological processes. Actin, microtubules, and nucleic acids can serve as one-dimensional tracks on which motor proteins move.

Filamentous polymers called microtubules play vital roles in chromosome segregation and molecular transport. An team has now examined how microtubule lengths vary in response to changes in the ...

In a groundbreaking study published today in the prestigious Proceedings of the National Academy of Sciences (PNAS), researchers from Queen Mary University of London and the University of Dundee have ...

Microtubules (MTs) are dynamic cytoskeleton polymers forming a polarized intracellular network that provides structural support, facilitates intracellular transport and drives chromosome segregation.

Atomic force microscopy (AFM) represents a better choice compared to light-based microscopy methods for the stufy of microtubules. For instance, the AFM can be used in buffers to image samples at a ...