EMBO Press

No guts, no glory: IL-26 in host-microbiota interactions

While IL-26 has been associated with a range of inflammatory conditions affecting the gut, including inflammatory bowel ...
EMBO Press

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding

The presence of Tau and TDP-43 co-aggregates is associated with high Alzheimer’s disease (AD) severity, but whether there is ...
The EMBO Journal

Deep learning for computational biology

Technological advances in genomics and imaging have led to an explosion of molecular and cellular profiling data from large numbers of samples. This rapid increase in biological data dimension and ...
The EMBO Journal

CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Protein quality control serves as the primary ...
The EMBO Journal

Structural insights into binding-site access and ligand recognition by human ABCB1

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ABCB1 is a broad-spectrum efflux pump central ...
The EMBO Journal

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Extracellular matrix (ECM) is a major ...
The EMBO Journal

The IRE1α/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Skeletal muscle regeneration involves a ...
The EMBO Journal

Human genomic DNA is widely interspersed with i-motif structures

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. DNA i-motif structures are formed in the ...
The EMBO Journal

The septin cytoskeleton is required for plasma membrane repair

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Plasma membrane repair is a fundamental ...
The EMBO Journal

ORP5/ORP8 localize to endoplasmic reticulum–mitochondria contacts and are involved in mitochondrial function

In addition to ER–PM contact sites, ORP5 and ORP8 also localize at ER–mitochondria contacts. ORP5/ORP8 interacts with the mitochondrial protein PTPIP51. ORP5/ORP8 targeting to ER–mitochondria contact ...
The EMBO Journal

Author Correction: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy

The authors contacted the journal after detecting an error in their paper. The authors provided the original source data for the affected figure. Upon review of the ...
The EMBO Journal

Gene therapy targeting key beta cell regulators as a potential intervention for diabetes

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Loss of functional beta cells is the central ...