Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. The recent discovery of early stage solution-state precursors ...
Transgenic and adeno-associated virus approaches were used to overexpress DWORF in the heart. Mice underwent transverse aortic constriction (TAC) to model pressure overload–induced heart failure.
Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Parapyruvate is a substance commonly found in commercial dietary supplements of ...
Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...
Pyruvate kinase deficiency, the most common genetic lesion in the glycolytic pathway, leads to chronic hemolytic anemia. Mitapivat, an oral agent, can activate some mutant enzymes and restore red-cell ...
Mitochondria have many functions in addition to their canonical metabolic role of energy generation. Mitochondria exist in dynamic networks and their non-canonical roles include (but are not limited ...
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