The calcium sensing receptor (CaSR) is a class C G protein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium ...

A single-cell understanding of microbe–microbe interactions is critical for unraveling the organization and dynamics of microbial communities. Through an unconventional application of expansion ...

After discussions with the U.S. Food and Drug Administration (FDA), Paris-based Ipsen withdrew its New Drug Application (NDA) for palovarotene. The drug is being developed for the prevention of ...

We present a general method to imbue proteins with heterotropic allostery by using surface protein supercharging to impart intrinsic disorder to the protein fold, allowing for functional activation by ...

The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin ...

1 Department of Chemical Sciences, University of Messina, Messina, Italy. 2 Biochemistry and Clinical Biochemistry Institute, Catholic University, School of Medicine ...

Selectins are a family of adhesion receptors designed for efficient leukocyte tethering to the endothelium under shear. As a key property to resist premature bond disruption, selectin adhesiveness is ...

Alterations in cytochrome P4503A4 are the most frequent underlying cause of drug-drug interactions (DDIs). This enzyme exhibits some unusual behaviors; for example, it has been observed that certain ...

ABSTRACT: Uncontrolled cell proliferation is the hall mark of many cancers, and is typically manifested by a deregulation of the cell-division cycle. CDKs play critical roles in regulating cell cycle, ...

In the version of this article initially published, the title included a misspelling—'heterotropic' should have been 'heterotopic'. Additionally, the fourth and fifth sentences of the abstract were ...