Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...

† † The Departments of Molecular Biology and ‡ The Skaggs Institute for Chemical Biology, and The Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Due to its key roles in malignant tumor progression and reprograming of the tumor ...

A person with episdermolysis bullosa simplex has hands with fragile skin peeling off and red blisters on their palms. (Wikimedia Commons/James Heilman, MD) What began as research about how integrins ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

The immune system plays a dual role in inflammation and cancer development. Immune system effector cells rapidly recognize and kill malignant cells; meanwhile, immune system-mediated inflammation ...

The 2022 Albert Lasker Basic Medical Research Award was jointly awarded to Richard O. Hynes, Erkki Ruoslahti, and Timothy A. Springer for their discoveries concerning proteins called integrins.

Soft tissue sarcomas are rare cancers of mesenchymal origin or differentiation comprising over 70 different histological subtypes. Due to their mesenchymal differentiation, sarcomas are thought to ...

Every keyboard has a set of Function Keys F1-F12 on the top row; however, the old computer sets used to have these keys gathered on the left side of the keyboard. While every function key caters ...

A recent study reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances antitumor responses. A recent ...

A recent study from the University of Helsinki reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the immune system, enhances ...