The immune dilemma. These cells are key: do they stop your autoimmunity or protect you from cancer?
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The immune dilemma. These cells are key: do they stop your autoimmunity or protect you from cancer?
Alex Nadal nos introduce al descubrimiento ganador del Premio Nobel de Medicina: las células T reguladoras (Tregs) y el gen FOXP3, los arquitectos del equilibrio inmunológico. Estas poderosas unidades operan como el freno natural del organismo, previniendo el ataque autoinmune. La carencia de estas células abre la puerta a condiciones como ...
1K views3 months ago
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TheTalas on Instagram: "The 2025 Nobel Prize in Physiology or Medicine was awarded not for a new drug or a single experiment, but for a fundamental explanation of why the immune system usually does not destroy the body it is meant to protect. For decades, immunology focused on how immunity attacks. What was missing was a clear answer to the opposite question: how immunity learns restraint. The laureates — Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi — solved this by uncovering the mechan
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[Wei Hu] Temporal and context-dependent requirements for the transcription factor Foxp3 expression..
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Regulatory T cells (Tregs) (CD4 CD25 FoxP3 ) are primarily targeted in cancer treatment to reverse their immunosuppressive effects within the tumor microenvironment, which allows tumors to escape immune surveillance. Strategies include depleting intratumoral Tregs, inhibiting their function, or modulating their metabolism to boost anti-tumor immune responses. Key aspects of Treg modulation in cancer treatment: Mechanism of Action: Tumors often show high infiltration of Tregs, which suppress effe
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Facebookrisesknowledge
Han pasado ya 30 años desde su descubrimiento y ayer recibieron el Premio Nobel. En 1995 Shimon Sakaguchi descubrió las células T reguladoras por primera vez, y en 2001 Mary Brunkow y Fred Ramsdell identificaron el gen FOXP3, clave para su desarrollo. #NobelMedicina2025 #Inmunología #nobel2025 #medicine #stem
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medicalmedia.kz on Instagram: "🏆 Нобелевская премия по медицине 2025 Три учёных получили Нобелевку за то, что раскрыли, почему иммунитет отличает “своё” от “чужого” — и почему иногда он атакует организм, вызывая аутоиммунные болезни. 🧬 В чём прорыв? Они изучили регуляторные T-клетки — главный «тормоз» иммунитета — и открыли ключевой ген FOXP3. Когда он ломается, иммунитет начинает разрушать собственные клетки. 🔬 Что это меняет? Их открытия стали основой будущих методов лечения: • диабета 1 ти
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