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Why Citrate Stops the Clot — the Blue Tube's Calcium Trick 🧪 Sodium citrate works by chelation: it binds calcium, clotting needs calcium, so the blood in the light blue top stays liquid and its clotting factors stay preserved. In the lab, a measured amount of calcium is added back and the PT/INR clock starts then — the trick is a pause, not a stop. That is why the fill matters: the tube is built for 9 parts blood to 1 part citrate. Underfill it, and the extra citrate grabs calcium during testin
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